Porcine Aorta Endothelial Cells (PAEC)

Product Description

Porcine Aorta Endothelial Cells (PAEC) line the vessel wall of aorta, and are constantly exposed to high hemodynamic forces. They produce endothelium-derived substances regulating vasoconstriction and vessel growth ^[1]. PAEC also modulate the expression of cellular adhesion molecules to control and fine-tune inflammatory responses and fibrinolysis ^[2]. These physiological properties allow PAEC cultures to be widely used in the study of mechanisms for endothelium dysfunction, pathogenesis of vascular diseases and atherosclerosis, and the development of novel disease treatments.

iXCells Biotechnologies provides high quality PAEC, which are isolated from porcine aorta and cryopreserved at P2, with >0.5 million cells in each vial. PAEC express CD31 and vWF/Factor VIII. They are negative for mycoplasma, bacteria, yeast, and fungi and can further expand for 14 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies

Figure 1. Porcine Aorta Endothelial Cells (PAECs). 

Product Details

References

[1]  Ando J, and Kamiya A. Flow-dependent regulation of gene expression in vascular endothelial cells. Heart J. 1996; 37:19-32.

[2]  Wynants M, et al and Quarck R. NF-kB pathway is involved in CRP-induced effects on pulmonary arterial endothelial cells in chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013; 305(12): L934-942.

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