Rat Mesenchymal Stem Cells - Bone Marrow (RMSC-bm)

Product Description

Mesenchymal stem cells (MSC) are a well-characterized population of adult stem cells. They have the potential to develop into mature cells that produce fat, cartilage, bone, tendons, and muscle [1, 2]. The developmental plasticity of MSC has generated tremendous interest because of the potential use of mesenchymal stem cells in regenerative medicine to replace damaged tissues. MSC cultured without serum in the presence of transformation growth factors will differentiate into chondrocytes. In contrast, MSC cultured in serum with ascorbic acid and dexamethasone will differentiate into osteoblasts. With their renewal capability, MSC have the potential to be transplanted into an injured site or seeded on a biomimetic scaffold to generate appropriate tissue constructs.

iXCells Biotechnologies provides high quality Rat Mesenchymal Stem Cells - Bone Marrow (RMSC-bm), which are isolated from adult rat bone marrow and cryopreserved at P1, with >0.5 million cells in each vial. RMSC-bm are positive for CD29, CD73, CD90, CD105, and negative for CD34, CD45. These cells are also characterized by lipid staining after differentiation. RMSC-bm are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 3-4 population Mesenchymal Stem Cell Medium (Cat# MD-0037) without losing their multipotent properties.  

Figure 1. Adipocyte differentiation from Rat MSC-bone marrow (oil red staining, Day 14 post adipogenic induction).

Product Details

References

[1] Kassem, M. Mesenchymal stem cells: biological characteristics and potential clinical applications. 2004. Cloning Stem Cells. 6(4):369-74.

[2] Barry, F. P., and J. M. Murphy. Mesenchymal stem cells: clinical applications and biological characterization. 2004. Int J Biochem Cell Biol. 36(4):568-84.

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 Adipocyte Differentiation Protocol