Human Bronchial Smooth Muscle Cells (HBSMC)

Product Description

Airway smooth muscle is fundamental for maintaining airway tone. The specialized ultrastructural features and regulatory mechanisms of airway smooth muscle are vital for normal airway function. Patients with respiratory disorders, such as severe asthma, exhibit the distinguishing feature of increased bronchial smooth muscle mass. The increase in smooth muscle mass is related either to abnormal bronchial smooth muscle cell (BSMC) proliferation or the accumulation of contractile protein. Smooth muscle cell proliferation is an important component of airway remodeling in asthma and is consequently a target for the development of novel anti-asthma agents. Airway smooth muscle cells express CT-1 [1] and release GM-CSF, RANTES and IL-8 in vitro [2]. In order to develop therapies for asthma, researchers have utilized BSMC to elucidate the cellular and molecular mechanisms underlying BSMC proliferation.

Figure 1.  Human Bronchial Smooth Muscle Cells (HBSMC) (phase contrast).

iXCells Biotechnologies provides high quality Human Bronchial Smooth Muscle Cells (HBSMC), which are isolated from human bronchi and bronchioles and cryopreserved at P1, with >0.5 million cells in each vial. HBSMC express α-smooth muscle actin and desmin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fung. HBSMC can further expand in Smooth Muscle Cell Growth Medium (Cat # MD-0034) under the condition suggested by iXCells Biotechnologies.

Product Details

References

[1] Zhou, D., Zheng, X., Wang, L., Stelmack, G., Halayko, A. J., Dorscheid, D. and Bai, T. R. (2003) Expression and effects of cardiotrophin-1 (CT-1) in human airway smooth muscle cells. British Journal of Pharmacology 140:1237-1244. 
[2] Oltmanns, U., Issa, R., Sukkar, M. B., John, M. and Chung, K. F. (2003) Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells. British Journal of Pharmacology 139:1228-1234.

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