Human Lung Microvascular Endothelial Cells (HLMVEC)

Product Description

The pulmonary vasculature is of great physiological/pathological significance. Human Lung Microvascular Endothelial Cells (HLMVEC) play an important role in regulating lung function. HLMVEC provide a useful tool for studying various aspects of pathology and biology of the pulmonary microvasculature in vitro ^[1].

iXCells Biotechnologies provides high quality HLMVEC, which are isolated from human lung tissue from a single donor and cryopreserved at P2, with >0.5 million cells in each vial. HLMVEC express vWF/Factor VIII and CD31 (PECAM). They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand in Endothelial Cell Growth Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies.

Figure 1.  HLMVECs provided by iXCells are positive for CD31 (A) and vWF (B), as shown by immunostaining. Flow analysis showed that more than 96% of cells are CD31 positive (A'), and more than 87% are vWF positive (B'). 

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References

[1]  Pacurari M, Qian Y, Fu W, Schwegler-Berry D, Ding M, Castranova V and Guo NL. Cell permeability, migration, and reactive oxygen species induced by multiwalled carbon nanotubes in human microvascular endothelial cells. J Toxicol Environ Health A. 2012; 75(3): 129-147. 

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