Human Peripheral Blood CD4+ Helper T Cells (Positive Selection)

Product Description

The CD4+ T cells, also known as T helper cells (T_h cells), are a type of T cells that play an important role in the immune system, particularly in the adaptive immune system ^[1]. CD4+ T cells can regulate immune response through different cytokines secreted ^[2]. They are essential in B cell antibody class switching, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages.

Considering the diverse and important role CD4+ T cells play in the immune system, it is not surprising that these cells often influence the immune response against disease. CD4+ T cells have been involved in hypersensitivity and as the main target cells of HIV pathogenesis.

iXCells Biotechnologies offers CD4+ T Cells isolated from normal human peripheral blood mononuclear cells (PBMCs) using positive immunomagnetic selection.  > 90% of the cells are CD4+ as showed by flow cytometric analysis (Figure 1).

Figure 1. The purity of CD4+ T cells are >90%. 

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References

[1]  Hu, J.; Paul, W. E. (2008). "CD4 T cells: Fates, functions, and faults". Blood 112 (5): 1557.

[2]  Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA. (2007). "Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death". Nat Immunol (8): 825–34.

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