Human Peripheral Blood CD8+ Cytotoxic T Cells (Positive Selection)

Product Description

The CD8+ T cells, also known as Cytotoxic T cells (T_C cells), are a type of T cells that kill cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways. Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen, and a glycoprotein called CD8 which binds to the constant portion of the class I MHC molecule. When exposed to infected/dysfunctional somatic cells, CD8+ T cells release the cytotoxins perforin, granzymes, and granulysin, which triggers the caspase cascade and eventually leads to apoptosis.  CD8+ T cells have been implicated in the pathogenesis of hepatitis B virus infection ^[1], arthritis ^[2] etc.

iXCells Biotechnologies offers CD8+ T cells isolated from normal human peripheral blood mononuclear cells (PBMCs) using positive immunomagnetic selection.  > 90% of the cells are CD8+ as showed by flow cytometric analysis (Figure 1).

Figure 1. Flow cytometric analysis showed that >90% of the cells are CD8+. 

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References

[1]  Iannacone, Matteo; Sitia, Giovanni; Guidotti, Luca G (2006). "Pathogenetic and antiviral immune responses against hepatitis B virus". Future Virology 1 (2): 189–96.

[2]   Subramanian S and Ramalingam K (2005). "Electron microscopic evidence on the participation Cytotoxic T Lymphocytes and Macrophages in Mtb adjuvant induced connective tissue inflammation and arthritogenesis in Rattus norvegicus". Asian Journal of Microbiology, Biotechnology and Environmental Sciences 7 (2): 227–233.

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