Human Umbilical Mesenchymal Stem Cells (HUMSC)

Product Description

Mesenchymal stem cells (MSC) are a well-characterized population of adult stem cells. MSC have the potential to develop into mature cells that produce fat, cartilage, bone, tendons, and muscle. These properties, in combination with their developmental plasticity, have generated tremendous interest because of the potential use of MSC in regenerative medicine. MSC isolated from the Wharton’s jelly of the umbilical cord were induced to transform into neurons and glia in vitro by using neuron-conditioned medium, sonic hedgehog, and FGF-8 [1, 2]. MSC can also differentiate into cells from the adipogenic and osteogenic lineage. Additionally, they have the potential to differentiate into cardiomyocytes by culturing them in cardiomyocyte-conditioned medium [3]. MSC express the matrix receptors CD44 and CD105 and mesenchymal stem cell markers SH2 and SH3, but not the hematopoietic lineage marker CD34.

iXCells Biotechnologies provides high quality Human  Umbilical Mesenchymal Stem Cells (HUMSC), which are isolated from Wharton’s jelly of the umbilical cord and cryopreserved at P1, with >0.5 million cells in each vial. HUMSC express CD73, CD90, and CD105. These HUMSC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 12 population doublings in Mesenchymal Stem Cell Medium (Cat# MD-0037) under the condition suggested by iXCells Biotechnologies.

Product Details

References

[1] Mitchell, K. E. et al. (2003) Matrix cells from Wharton's jelly form neurons and glia. Stem Cells 21:50-60. 
[2] Fu, Y. S. et al. (2006) Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonium. Stem cells 24:115-124. 
[3] Wang, H. S., et al., (2004) Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem cells 22:1330-1337.