Human Bladder Epithelial Cells (HBlEpC)

Product Description

The bladder epithelium forms an effective multifactorial barrier to urine, toxic metabolites, and pathogens.  Additionally, the presence of aquaporins (AQPs), urea transporters, and ion channels indicates that the bladder epithelium has all the machinery necessary to actively alter the composition of the urine.  Therefore, this tissue may play an unappreciated but important role in water, salt, and solute homeostasis.  One of the most exciting functions of the bladder epithelium is its potential role as a sensory transducer.  By receiving, amplifying, and transmitting information, the bladder epithelium can convey information about the mucosa and urinary space to the nervous and muscular systems and help coordinate bladder function during filling and voiding. Human bladder epithelial cells (HBlEpC) have been suggested as a powerful tool in studying bladder epithelial development and function, mechanisms of cancerogenesis, especially those related to urothelial carcinoma of the bladder, as well as the processes by which epithelial cells achieve and maintain their specialized plasma membrane domains, and how these functions are disrupted in disease.

iXCells Biotechnologies provides high quality HBlEpC, which are isolated from normal human bladder and cryopreserved at P2, with >0.5 million cells in each vial. HAEpC express cytokeratin-18 and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HBIEpc can further expand for 5 population doublings in Epithelial Cell Growth Medium (Cat# MD-0041) under the condition suggested by iXCells Biotechnologies.

Product Details

References

[1] Song, M., J. Lim, H. Yu, J. Park, J. Chun, J. Jeong, J. Heo, H. Kang, Y. Kim, Y. Cho, S. Kim, W. Oh, S. Choi, S. Jang, S. Park, D. Shin, and M. Choo. 2015. Mesenchymal stem cell therapy alleviates interstitial cystitis by activating Wnt signaling pathway. Stem Cell and Development, 6 March. 
[2] Hattori, S., K. Kojima, K. Minoshima, M. Yamaha, M. Horie, T. Sawamura, A. Kikuchi, and T. Deguchi. 2014. Detection of Bladder Cancer by Measuring CD44v6 Expression in Urine With Real-time Quantitative Reverse Transcription Polymerase Chain Reaction. Urology, 83:1443.e9-1443.e15.