Human Synoviocytes (HS)

Product Description

Human synoviocytes (HS), the predominant cell type of healthy synovial tissue, are fibroblast-like cells. Synoviocytes form a distinct structure called the synovial lining layer [1]. Synoviocytes produce synovial fluid, are responsible for absorption from the joint cavity and are in control of blood/synovial fluid exchanges. Synoviocytes proliferate, show anchorage-independent growth, and secrete a variety of effector molecules that promote inflammation and joint destruction. In addition, they are part of a complex network of autocrine and paracrine acting factors. Synoviocytes provide new insight into synovial tissue organization and morphogenesis and are a potential therapeutic target [2].

iXCells Biotechnologies provides high quality Human synoviocytes (HS), which are isolated from human synovium and cryopreserved at P1, with >0.5 million cells in each vial. HS express CD90 and fibronectin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fung. HS can further expand for 16 population doublings in Synoviocyte Growth Medium (Cat# MD-0056) under the condition suggested by iXCells Biotechnologies. 

Product Details

References

[1]. Barland, P., Novikoff, A.B., Hamerman, D. (1962) Electron microscopy of the human synovial membrane. J Cell Biol. 14:207-220. 
[2]. Kiener , H. P. and Brenner, M. B. (2005) Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion. Arthritis Res Ther. 7(2): 49-54.