Human Pancreatic Stellate Cells (HPSC)

Product Description

Human Pancreatic Stellate Cells (HPSC) are the main fibroblastic cells of the pancreas. HPSC are responsible for the synthesis and the degradation of the extracellular matrix proteins that promote tissue repair. They are found adjacent to pancreatic acinar cells and around small pancreatic ducts and blood vessels. When HPSC are activated, they assume myofibroblast-like morphology and secrete excessive amounts of extracellular matrix proteins, which can lead to desmoplasia in chronic pancreatitis and adenocarcinoma [1,2]. Recent studies have shown that HPSC can also act as progenitor cells, immune cells, and intermediaries in exocrine pancreatic secretion [3]. Additionally, HPSC stimulate pancreatic cancer proliferation, inhibit apoptosis, and enhance angiogenesis [2]. HPSC are the ideal model for studying pancreatic tumor formation and they can be used to develop novel therapies for treatment of chronic pancreatitis and adenocarcinoma. 

iXCells Biotechnologies offers HPSC from human pancreas. HPSC are cryopreserved after purification and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HPSC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HPSC can be further expanded  in Stellate Cell Growth Medium (Cat # MD-0014).

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References

[1] Erkan, M., Hausmann, S., Michalski, C., Schlitter, M., Fingerle, A,. Friess, H., and Kleeff, J. (2012). How fibrosis influences imaging and surgical decision in pancreatic cancer. Front. Physio. 3:389. 
[2] Apte, M., Pirola, R., and Wilson, J. (2012). Pancreatic stellate sells: A starring role in normal and diseased pancreas. Front. Physio. 3:344. 
[3] Mato, E., Lucas, M., Petriz, J., Gomis, R., and Novials, A. (2009). Identi?cation of a pancreatic stellate cell population with properties of progenitor cells: new role for stellate cells in the pancreas. Biochem. J. 421:181.
[4] Shimizu, K., Kobayashi, M., Tahara, J., and Shiratori, K. (2005). Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells. Gastroenterology. 128: 2105.
[5] Phillips, P. A.,Yang, L., Shulkes, A., Vonlaufen, A., Poljak, A., Bustamante, S., Warren, A., Xu, Z.,Guilhaus, M., Pirola, R.,Apte, M. V., and Wilson, J. S. (2010). Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion. Proc. Natl. Acad. Sci. U.S.A. 107:17397.

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