Human iPS Cell Line (Alzheimer's Disease)

Product Description

Alzheimer’s disease (AD) is a progressive neurodegenerative disease. AD patients suffer from slow deterioration of memory and cognitive functions, which may eventually lead to death. AD is the most common form of dementia and it is estimated that more than 6 million American are living with AD in 2019. The genetic causes are largely unknown in sporadic AD (sAD) while few genetic aberrations have been identified in familiar AD (fAD). However, no effective treatments have been developed to slow down or change the disease course.

iXCells Biotechnologies have generated human induced pluripotent stem cells (hiPSCs) derived from a patient with familiar Alzheimer’s disease (fAD). These iPS cells are established from a single clone and expanded in feeder-free conditions. The Certificate of Analysis (COA) is provided for each cell lot purchased. The cells have been fully characterized for their self-renewal and pluripotent markers (Figure 1). All the cells provided by iXCells Biotechnologies are negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C. Recently, hiPSCs have been shown to serve as a versatile tool to investigate and model various diseases including AD and other neurodegenerative diseases. Therefore, our hiPSCs carrying fAD mutation (PSEN2 N141I) will meet the clients’ need to study the molecular basis of AD progression and further to develop potential therapeutic approaches.

Normal human iPS cell lines are available as separate products (Cat# 30HU-002). In addition, we provide human iPSC lines derived from individuals diagnosed with various diseases including Parkinson's Disease (PD) (Cat# 30HU-003), Amyotrophic Lateral Sclerosis (ALS) (Cat# 30HU-004), and Type 2 Diabetes (T2D) (Cat# 30HU-005). More disease-associated human iPS cell lines are under development. We also provide custom iPSC generation, gene editing and iPSC direct differentiation services to meet your needs.

 Figure 1. Characterization of human AD iPSC. Our human AD hiPSCs show typical human embryonic stem cell morphology (Phase Contrast) and strong alkaline phosphatase activity (AP).These cells also obtain strong self-renewal and pluripotent markers (OCT-3/4, NANOG, TRA-1-81, and TRA-1-60). Cell nuclei were stained with DAPI as counter staining. Scale bars are depicted in each panel.

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References

[1] Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S. A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011 May; 8(5):409-12.